Calcium and Bone Metabolism Disorders During Pregnancy

Calcium and Bone Metabolism
Disorders During Pregnancy

Dr. Mitra Niafar

Professor of Endocrinology and Metabolism

Tabriz University of Medical Sciences

Pregnancy and Ca-P homeostasis

Pregnancy is associated with substantial changes in calcium-phosphate homeostasis, resulting from pregnancy induced alterations in:

Synthesis, Tissue effects & Excretion of hormones related to calcium-phosphate metabolism.

Adaptations During Pregnancy

The human fetus accretes about 30 g of calcium by term, with 80% of it obtained during the third trimester.
Intestinal calcium absorption more than doubles during pregnancy to meet this increased demand for calcium.
This upregulation is mediated by calcitriol , prolactin , placental lactogen, and possibly by other factors.

Bone & Mineral Metabolism During Pregnancy